Traditionally, perfume should only be applied strongly enough to be smelled 12 inches away.  But no matter how delicate the application, some people with sensitive allergies would prefer that you forgo the use of scent completely when you will be traveling in a closed container such as an airplane.  As with most things, moderation is best.

Application

Apply your perfume after showering or bathing, but if you have time, wait a few minutes since you've washed away the body oil that helps hold the scent on your skin.

Don't rub perfume into your skin because it breaks down the scent.  Let it air dry by waving your arms.  You'll be getting very mild exercise to boot!

Let perfume dry completely so the alcohol in it won't stain your clothes. 

Wait until your perfume is dry before applying jewelry, including pearls or beads, so it won't discolor them.

Layering scented lotion with perfume on top will make the scent last much long.

More tricks and tips

Don't buy large bottles of perfume.  You might tire of the scent.  Instead, purchase several different smaller sized perfumes to go with different moods you may be feeling.